The Outcome of Induction Therapy for EBV-Related Hemophagocytic Lymphohistiocytosis: A Model for Risk Stratification.

ABSTRACT:

Background

Epstein-Barr virus (EBV)-related hemophagocytic lymphohistiocytosis (HLH) is an abnormal inflammation caused by EBV infection, which has high mortality during induction therapy.

Objectives

This study is aimed to build a model to predict the risk of death during induction therapy.

Methods

The patients with EBV-HLH admitted from January 2015 to December 2018 were retrospectively reviewed. The primary outcome was death during induction therapy. The interval from receiving therapy to death or the end of induction therapy was the observing time. The patients admitted from January 2015 to December 2017 were assigned to the primary group, and the patients admitted from January to December 2018 were assigned to the validation group.

Results

We included 234 p

SUBMITTER: Cui T 

PROVIDER: S-EPMC9289144 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature