Nanozyme Hydrogels for Self-Augmented Sonodynamic/Photothermal Combination Therapy.

ABSTRACT: Sonosensitizer-mediated sonodynamic therapy (SDT) has emerged as a promising anti-tumor strategy. However, this strategy of continuous oxygen consumption further exacerbates the hypoxic tumor microenvironment, which limits its therapeutic efficacy. In this study, we designed a multifunctional hydrogel (PB+Ce6@Hy) that simultaneously co-delivers nanozyme prussian blue (PB) and sonosensitizer chlorin e6 (Ce6) for the realization of photothermal therapy (PTT) and enhanced SDT. When the hydrogel reaches the tumor tissue through local injection, the 808 nm laser can induce the hydrogel to warm up and soften, thereby triggering the release of PB and Ce6. PB can interact with endogenous H₂O₂ in situ and generate sufficient oxygen to promote the Ce6-mediated SDT effect

SUBMITTER: Wang S 

PROVIDER: S-EPMC9289279 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature