Comprehensive Analysis of the Brain-Expressed X-Link Protein Family in Glioblastoma Multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common, malignant, and deadly primary brain tumor in adults. Brain-expressed X-link (BEX) protein family is involved in tumorigenesis. Here, we have explored the biological function and the prognostic value of the BEX family in GBM. Differentially expressed BEX genes between GBM and normal tissue were screened by using The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analyses identified the prognosis-related genes BEX1, BEX2, and BEX4, which were involved in the regulation of immune response. The results of correlation analysis and protein-protein interaction network (PPI network) showed that there was a significant correlation between the BEX family and TCEAL family in GBM. Furthermore, the expression of transcri

SUBMITTER: Aisa A 

PROVIDER: S-EPMC9289282 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature