Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.

ABSTRACT: Glutamine is a conditionally essential amino acid involved in energy production and redox homeostasis. Aging is commonly characterized by energy generation reduction and redox homeostasis dysfunction. Various aging-related diseases have been reported to be accompanied by glutamine exhaustion. Glutamine supplementation has been used as a nutritional therapy for patients and the elderly, although the mechanism by which glutamine availability affects aging remains elusive. Here, we show that chronic glutamine deprivation induces senescence in fibroblasts and aging in Drosophila melanogaster, while glutamine supplementation protects against oxidative stress-induced cellular senescence and rescues the D-galactose-prompted progeria phenotype in mice. Intriguingly, we found that long-term

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9289448 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature