Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback.

ABSTRACT: The heart pumps blood into circulation against vascular resistance and actively regulates the contractile force to compensate for mechanical load changes. Our experimental data show that cardiomyocytes have a mechano-chemo-transduction (MCT) mechanism that increases intracellular Ca 2 + transient to enhance contractility in response to increased mechanical load. This study advances the cardiac excitation- Ca 2 + signaling-contraction (E-C) coupling model on conceptual and technical fronts. First, we developed analytical and computational models to perform 3-dimensional mechanical analysis of cardiomyocytes contracting in a viscoelastic medium under mechanical load. Next, we proposed an MCT feedback loop in the E-C coupling dynamic system to shift the feedforward paradigm of cardiac

SUBMITTER: Kazemi-Lari MA 

PROVIDER: S-EPMC9289640 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature