Characteristics of Fatty Acid Metabolism in Lung Adenocarcinoma to Guide Clinical Treatment.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) has a very high morbidity and mortality rate, and its pathogenesis and treatment are still in the exploratory stage. Fatty acid metabolism plays a significant role in tumorigenesis, progression, and immune regulation. However, the gene expression of fatty acid metabolism in patients with LUAD and its relationship with prognosis remain unclear.

Methods

We collected 309 fatty acid metabolism-related genes, established a LUAD risk model based on The Cancer Genome Atlas (TCGA) using Least Absolute Shrinkage Selection Operator (LASSO) regression analysis, and divided LUAD patients into high-risk and low-risk groups, which were further validated using the Gene Expression Omnibus (GEO) database. The nomogram, principal component analysis (PCA),

SUBMITTER: Huang D 

PROVIDER: S-EPMC9289740 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature