Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume.

ABSTRACT:

Background

Individual differences in stress appraisals influence trajectories of risk and resilience following exposure to chronic and acute stressors. Smaller hippocampal volume may contribute to elevated stress appraisals via deficient pattern separation, a process depending on dentate gyrus (DG)/CA3 hippocampal subfields. Here, we investigated links between perceived stress, DG/CA3 volume, and behavioral pattern separation to test hypothesized mechanisms underlying stress-related psychopathology.

Methods

We collected the Perceived Stress Scale (PSS) and ratings of subjective stress reactivity during the Trier Social Stress Test (TSST) from 71 adult community participants. We obtained high-resolution T2 MRI scans and used Automatic Segmentation of Hippocampal Subfields to

SUBMITTER: Grupe DW 

PROVIDER: S-EPMC9289864 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature