Rationalizing Sequence and Conformational Effects on the Guanine Oxidation in Different DNA Conformations.

ABSTRACT: The effect of the environment on the guanine redox potential is studied by means of a theoretical-computational approach. Our data, in agreement with previous experimental findings, clearly show that the presence of consecutive guanine bases in both single- and double-stranded DNA oligomers lowers their reduction potential. Such an effect is even more marked when a G-rich quadruplex is considered, where the oxidized form of guanine is particularly stabilized. To the best of our knowledge, this is the first computational study reporting on a quantitative estimate of the dependence of the guanine redox potential on sequence and conformational effects in complex DNA molecules, ranging from single-stranded DNA to G-quadruplex.

SUBMITTER: Nardi AN 

PROVIDER: S-EPMC9289878 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature