Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation.

ABSTRACT: E3s comprise a structurally diverse group of at least 800 members, most of which target multiple substrates through specific and regulated protein-protein interactions. These interactions typically rely on short linear motifs (SLiMs), called "degrons", in an intrinsically disordered region (IDR) of the substrate, with variable rules of engagement governing different E3-docking events. These rules of engagement are of importance to the field of targeted protein degradation (TPD), where substrate ubiquitination and destruction require tools to effectively harness ubiquitin ligases (E3s). Substrates are often found to contain multiple degrons, or multiple copies of a degron, contributing to the affinity and selectivity of the substrate for its E3. One important paradigm for E3-substrate docki

SUBMITTER: Okoye CN 

PROVIDER: S-EPMC9289945 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature