Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case-control study.

ABSTRACT:

Background

Coagulation cascade contributes to thrombotic and hemorrhagic diseases, but it remains unclear whether coagulation factors X (FX) and XI (FXI) levels are associated with cardiovascular diseases.

Objective

To evaluate prospective associations of FX and FXI levels with incident acute coronary syndrome (ACS), stroke, and their subtypes (acute myocardial infarction, unstable angina, ischemic stroke, and hemorrhagic stroke).

Methods

We performed a nested case-control study (n = 1846) within the Dongfeng-Tongji cohort from 2013 to 2016 matched on age (within 1 year), sex, and sampling date (within 1 month) by incidence density sampling, and measured plasma FX and FXI levels by enzyme-linked immunosorbent assay. FX and FXI levels were categorized into three groups

SUBMITTER: Chen H 

PROVIDER: S-EPMC9290014 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature