Evidence for microscopic kurtosis in neural tissue revealed by correlation tensor MRI.

ABSTRACT:

Purpose

The impact of microscopic diffusional kurtosis (µK), arising from restricted diffusion and/or structural disorder, remains a controversial issue in contemporary diffusion MRI (dMRI). Recently, correlation tensor imaging (CTI) was introduced to disentangle the sources contributing to diffusional kurtosis, without relying on a-priori multi-gaussian component (MGC) or other microstructural assumptions. Here, we investigated µK in in vivo rat brains and assessed its impact on state-of-the-art methods ignoring µK.

Theory and methods

CTI harnesses double diffusion encoding (DDE) experiments, which were here improved for speed and minimal bias using four different sets of acquisition parameters. The robustness of the improved CTI protocol was assessed via simulations. In vi

SUBMITTER: Henriques RN 

PROVIDER: S-EPMC9290035 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature