Toxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science.

ABSTRACT: Toxicoepigenetics examines the health effects of environmental exposure associated with, or mediated by, changes in the epigenome. Despite high expectations, toxicoepigenomic data and methods have yet to become significantly utilized in chemical risk assessment. This article draws on a social science framework to highlight hitherto overlooked structural barriers to the incorporation of toxicoepigenetics in risk assessment and to propose ways forward. The present barriers stem not only from the lack of maturity of the field but also from differences in constraints and standards between the data produced by toxicoepigenetics and the regulatory science data that risk assessment processes require. Criteria and strategies that frame the validation of knowledge used for regulatory purposes limit

SUBMITTER: Le Goff A 

PROVIDER: S-EPMC9290111 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature