HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis.

ABSTRACT:

Objectives

Lower high-density lipoprotein cholesterol (HDL-C) levels have been observed in chronic liver disease patients. The aim of this study was to develop a model that incorporates HDL-C levels and the Model for End-stage Liver Disease (MELD) score to predict 30-day mortality in Asian cirrhosis patients.

Methods

Cirrhosis patients were recruited from two hospitals in this retrospective observational study. Propensity score matching was used. The model's performance was evaluated, including its ability to predict 30-day mortality, accuracy, and clinical utility. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were calculated.

Results

The HDL-C + MELD model showed good ability to predict 30-day mortality (area under the curve,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9290124 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature