Prognostic/predictive markers in systemic therapy resistance and metastasis in breast cancer.

ABSTRACT: Breast cancer is a highly heterogeneous group of diseases posing a significant challenge in biomarker-driven research and the development of effective targeted therapies. Especially the treatment of metastatic breast cancer poses even more challenges, as we still lose more than 42,000 women and men each year in the United States alone. New biological insight helps to improve breast cancer treatment through early detection, adaptation to chemotherapy resistance, and tailoring to find the right size of care. This review focuses on existing and new areas of predictive biomarkers under development to tailor the management of breast cancer and the application of integrative approaches that have resulted in the promising candidate biomarker discovery. Furthermore, we review new methods to detect

SUBMITTER: Hobbs EA 

PROVIDER: S-EPMC9290149 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature