Persistent white matter vulnerability in a mouse model of mild traumatic brain injury.

ABSTRACT:

Background

Following one mild traumatic brain injury (mTBI), there is a window of vulnerability during which subsequent mTBIs can cause substantially exacerbated impairments. Currently, there are no known methods to monitor, shorten or mitigate this window.

Methods

To characterize a preclinical model of this window of vulnerability, we first gave male and female mice one or two high-depth or low-depth mTBIs separated by 1, 7, or 14 days. We assessed brain white matter integrity using silver staining within the corpus callosum and optic tracts, as well as behavioural performance on the Y-maze test and visual cliff test.

Results

The injuries resulted in windows of white matter vulnerability longer than 2 weeks but produced no behavioural impairments. Notably, this windo

SUBMITTER: Velayudhan PS 

PROVIDER: S-EPMC9290236 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature