Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors.

ABSTRACT:

Background

The fungal natural products illudin S and M have been investigated as precursors for the development of semisynthetic anticancer agents such as Irofulven (illudin S derivative) which is currently in phase II clinical trials. Recently, illudin M derivatives have shown improved in vitro selectivity towards cancer cells encouraging further investigation. This requires a stable supply of the precursor which is produced by Basidiomycota of the genus Omphalotus. We have recently reported a robust shake flask process for the production of gram quantities of illudin M from Omphalotus nidiformis aiming to transfer that process into stirred tank bioreactors, which can be used in a commercial production set-up. However, process transfer across different systems is not straightforwa

SUBMITTER: Chaverra-Munoz L 

PROVIDER: S-EPMC9290264 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature