Mesenchymal stem cell transplantation alleviated atherosclerosis in systemic lupus erythematosus through reducing MDSCs.

ABSTRACT:

Objective

The mechanism by which mesenchymal stem cell (MSC) transplantation alleviates atherosclerosis in systemic lupus erythematosus (SLE) remains elusive. In this study, we aim to explore the efficacy and mechanism of MSC in ameliorating atherosclerosis in SLE.

Methods

ApoE^-/- and Fas^-/- mice on the B6 background were cross-bred to generate SLE mice with atherosclerosis. Myeloid-derived suppressor cells (MDSCs) were sorted and quantified. The apoE^-/-Fas^-/- mice were either treated with anti-Gr antibody or injected with MDSCs. The lupus-like autoimmunity and atherosclerotic lesions were evaluated. Furthermore, the apoE^-/-Fas^-/- mice were transplanted with MSCs and lupus-like autoimmunity and atherosclerotic

SUBMITTER: Yao G 

PROVIDER: S-EPMC9290280 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature