Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity

ABSTRACT:

Background

Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets as an adjunctive cancer therapy. However, it is unclear which genetic, metabolic, or immunological factors contribute to the beneficial effect of ketogenic diets. Therefore, we investigated the effect of ketogenic diets on the progression and metabolism of genetically and metabolically heterogeneous melanoma xenografts, as well as on the development of melanoma metastases in mice with a functional immune system.

Methods

Mice bearing BRAF mutant, NRAS mutant, and wild-type melanoma xenografts as well as mice bearing highly metastatic melanoma allografts were fed with a control diet or ketogenic diets, differing in their triglyceride composition, to evaluate the effect of ketogenic die

SUBMITTER: Weber D 

PROVIDER: S-EPMC9290281 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature