Inhaled corticosteroids, COPD, and the incidence of lung cancer: a systematic review and dose response meta-analysis.

ABSTRACT:

Background

There has been debate on whether inhaled corticosteroids (ICS) reduce the incidence of lung cancer amongst patients with Chronic Obstructive Lung Disease (COPD). We aimed to perform a systematic review and dose-response meta-analysis on available observational data.

Methods

We performed both a dose response and high versus low random effects meta-analysis on observational studies measuring whether lung cancer incidence was lower in patients using ICS with COPD. We report relative risk (RR) with 95% confidence intervals (CI), as well as risk difference. We use the GRADE framework to report our results.

Results

Our dose-response suggested a reduction in the incidence of lung cancer for every 500 ug/day of fluticasone equivalent ICS (RR 0.82 [95% 0.68-0.95]).

SUBMITTER: Pitre T 

PROVIDER: S-EPMC9290283 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature