The association of vitamin D binding protein levels and genotypes with type 1 diabetes in the black South African population.

ABSTRACT:

Background

Vitamin D deficiency and the vitamin D pathway have previously been associated with type 1 diabetes (T1D). The majority of vitamin D is transported through the blood bound to the vitamin D binding protein (VDBP). Two polymorphisms in the VDBP gene (rs4588 and rs7041) result in different VDBP variants and have been associated with T1D, however the results are not consistent. The association of VDBP levels and its polymorphisms with T1D have not been investigated in the black South African population. Therefore, this study aimed to determine whether rs4588, rs7041 or serum VDBP levels were associated with T1D in this population.

Methods

Participants with type 1 diabetes and controls were recruited from the greater Johannesburg area, South Africa. Participants were g

SUBMITTER: Cave EM 

PROVIDER: S-EPMC9290305 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature