Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction.

ABSTRACT: The liver vascular network is patterned by sinusoidal and hepatocyte co-zonation. How intra-liver vessels acquire their hierarchical specialized functions is unknown. We study heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing. The acquisition of sinusoidal endothelial cell identity is initiated during early development and completed postnatally, originating from a pool of undifferentiated vascular progenitors at E12. The peri-natal induction of the transcription factor c-Maf is a critical switch for the sinusoidal identity determination. Endothelium-restricted deletion of c-Maf disrupts liver sinusoidal development, aberrantly expands postnatal liver hematopoiesis, promotes excessive postnatal sinusoidal proliferation, and ag

SUBMITTER: Gomez-Salinero JM 

PROVIDER: S-EPMC9290393 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature