Dermoscopy comparative approach for early diagnosis in familial melanoma: influence of MC1R genotype.

ABSTRACT:

Background

MC1R polymorphisms interact with CDKN2A mutations modulating melanoma risk and contribute to a less suspicious clinical and dermoscopic appearance of melanomas. Different strategies, including dermoscopic comparative approach and digital monitoring, are used for the melanoma diagnosis in this context.

Objective

To analyse the diagnostic accuracy of the morphologic approach and comparative approach in dermoscopy, and to detect melanoma in familial melanoma (FamMM) patients according to different genetic backgrounds.

Methods

Two independent readers evaluated 415 lesions belonging to 25 FamMM: 26 melanomas (62% in situ, 36% early invasive) and 389 naevi, blinded for dermoscopic and histopathologic diagnosis, following two different steps. First step-Randomized

SUBMITTER: Longo C 

PROVIDER: S-EPMC9290446 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature