A systematic review and meta-analyses on animal models used in bone adhesive research.

ABSTRACT: Currently, steel implants are used for osteosynthesis of (comminuted) fractures and intra-articular bone defects. These osteosyntheses can sometimes be complicated procedures and can have several drawbacks including stress shielding of the bone. A bone glue might be a safe and effective alternative to current materials. Despite numerous animal studies on bone adhesives, no such material is clinically applied yet. We have conducted a systematic review to summarize the evidence in experimental animal models used in research on bone adhesive materials for trauma and orthopedic surgery. Additionally, we analysed the efficacy of the different bone adhesives for different experimental designs. A heterogeneity in experimental parameters including animal species, defect types, and control measurem

SUBMITTER: Van Erk M 

PROVIDER: S-EPMC9290478 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature