Statin liver safety in non-alcoholic fatty liver disease: A systematic review and metanalysis.

ABSTRACT:

Aims

Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT), aspartate transaminase (AST) and gamma-glutamyl transpeptidase (GGT) in NAFLD patients treated or not treated with statins.

Methods

We performed a systematic review of MEDLINE via PubMed and EMBASE databases and metanalysis of clinical studies investigating levels of ALT, AST and GGT in NAFLD according to statin treatment. Mean difference (MD) and percentage MD were calculated between the two groups.

Results

We included 22 studies with 2345 NAFLD patients. Overall, 16 were before-after interventional, five were cross-sectional and one was combined cross-sectional/inte

SUBMITTER: Pastori D 

PROVIDER: S-EPMC9290532 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature