Risk Factors for Hospitalization or Death Among Adults With Advanced HIV at Enrollment for Care in South Africa: A Secondary Analysis of the TB Fast Track Trial.

ABSTRACT:

Background

Individuals with advanced HIV experience high mortality, especially before and during the first months of antiretroviral therapy (ART). We aimed to identify factors, measurable in routine, primary health clinic-based services, associated with the greatest risk of poor outcome.

Methods

We included all individuals enrolled in the standard-of-care arm of a cluster-randomized trial (TB Fast Track); adults attending participating health clinics with CD4 ≤150 cells/µL and no recent ART were eligible. Associations between baseline exposures and a composite outcome (hospitalization/death) over 6 months were estimated using multivariable Cox regression.

Results

Among 1515 individuals (12 clinics), 56% were female, the median age was 36 years, and the median CD4 coun

SUBMITTER: Calderwood CJ 

PROVIDER: S-EPMC9290545 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature