Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats.

ABSTRACT: Chronic stress produces long-term metabolic changes throughout the superfamily of nuclear receptors, potentially causing various pathologies. Sex hormones modulate the stress response and generate a sex-specific age-dependent metabolic imprint, especially distinct in the reproductive senescence of females. We monitored chronic stress recovery in two age groups of female Sprague Dawley rats to determine whether stress and/or aging structurally changed the glycolipid microenvironment, a milieu playing an important role in cognitive functions. Old females experienced memory impairment even at basal conditions, which was additionally amplified by stress. On the other hand, the memory of young females was not disrupted. Stress recovery was followed by a microglial decrease and an increase in as

SUBMITTER: Balog M 

PROVIDER: S-EPMC9290558 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature