Unraveling the MRI-Based Microstructural Signatures Behind Primary Progressive and Relapsing-Remitting Multiple Sclerosis Phenotypes.

ABSTRACT:

Background

The mechanisms driving primary progressive and relapsing-remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown. Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in the degeneration, highlighting its damage as an early feature of both phenotypes. However, the role of GM microstructure is unclear, calling for new methods for its decryption.

Purpose

To investigate the morphometric and microstructural GM differences between PPMS and RRMS to characterize GM tissue degeneration using MRI.

Study type

Prospective cross-sectional study.

Subjects

Forty-five PPMS (26 females) and 45 RRMS (32 females) patients.

Field strength/sequence

3T scanner. Three-dimensional (3D) fast field echo T1-weighted (T1-w), 3D tu

SUBMITTER: Boscolo Galazzo I 

PROVIDER: S-EPMC9290631 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature