Detection of Babesia RNA and DNA in whole blood samples from US blood donations.

ABSTRACT:

Background

Human babesiosis is a zoonotic infection caused by an intraerythrocytic parasite. The highest incidence of babesiosis is in the United States, although cases have been reported in other parts of the world. Due to concerns of transfusion-transmitted babesiosis, the US Food and Drug Administration (FDA) recommended year-round regional testing for Babesia by nucleic acid testing or use of an FDA-approved device for pathogen reduction. A new molecular test, cobas Babesia (Roche Molecular Systems, Inc.), was evaluated for the detection of the four species that cause human disease, Babesia microti, Babesia duncani, Babesia divergens, and Babesia venatorum.

Study design and methods

Analytical performance was evaluated followed by clinical studies on whole blood samples f

SUBMITTER: Stanley J 

PROVIDER: S-EPMC9290686 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature