Slow oscillations open susceptible time windows for epileptic discharges.

ABSTRACT:

Objective

In patients with epilepsy, interictal epileptic discharges are a diagnostic hallmark of epilepsy and represent abnormal, so-called "irritative" activity that disrupts normal cognitive functions. Despite their clinical relevance, their mechanisms of generation remain poorly understood. It is assumed that brain activity switches abruptly, unpredictably, and supposedly randomly to these epileptic transients. We aim to study the period preceding these epileptic discharges, to extract potential proepileptogenic mechanisms supporting their expression.

Methods

We used multisite intracortical recordings from patients who underwent intracranial monitoring for refractory epilepsy, the majority of whom had a mesial temporal lobe seizure onset zone. Our objective was to evalua

SUBMITTER: Sheybani L 

PROVIDER: S-EPMC9290693 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature