Ontology highlight
ABSTRACT: Background
Hodgkin's lymphoma (HL) survivors treated with abdominal radiotherapy and/or procarbazine have an increased risk of developing colorectal neoplasia.Aims
We evaluated the clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in HL survivors.Methods
In all, 101 HL survivors (median age 51 years, median age of HL diagnosis 25 years) underwent colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas/serrated lesions or colorectal cancer), mostly right-sided, were detected, as published previously. An average-risk asymptomatic cohort who underwent screening colonoscopy were controls (median age 60 years). Clinicopathological characteristics of AN were evaluated in both groups. Mismatch repair (MMR) status was assessed using immunohistochemistry (MLH1/MSH2/MSH6/PMS2). Logistic regression analysis was performed to evaluate the risk factors for AN in HL survivors, including age at HL diagnosis and interval between HL and colonoscopy.Results
In 101 colonoscopies in HL survivors, AN was primarily classified based on polyp size ≥10 mm, whereas (high-grade)dysplasia was more often seen in AN in controls. An interval between HL diagnosis and colonoscopy >26 years was associated with more AN compared with an interval of <26 years, with an odds ratio for AN of 3.8 (95% confidence interval 1.4-9.1) (p < 0.01). All 39 AN that were assessed were MMR proficient.Conclusions
Colorectal neoplasia in HL survivors differ from average-risk controls; classification AN was primarily based on polyp size (≥10 mm) in HL survivors. Longer follow-up between HL diagnosis and colonoscopy was associated with a higher prevalence of AN in HL survivors.
SUBMITTER: Ykema BLM
PROVIDER: S-EPMC9290704 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Ykema Berbel L M BLM Rigter Lisanne S LS Spaander Manon C W MCW Moons Leon M G LMG Bisseling Tanya M TM Aleman Berthe M P BMP Dekker Evelien E Verbeek Wieke H M WHM Kuipers Ernst J EJ de Boer Jan Paul JP Lugtenburg Pieternella J PJ Janus Cecile P M CPM Petersen Eefke J EJ Roesink Judith M JM van der Maazen Richard W M RWM Meijer Gerrit A GA Schaapveld Michael M van Leeuwen Flora E FE Carvalho Beatriz B Snaebjornsson Petur P van Leerdam Monique E ME
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 20210608 1
<h4>Background</h4>Hodgkin's lymphoma (HL) survivors treated with abdominal radiotherapy and/or procarbazine have an increased risk of developing colorectal neoplasia.<h4>Aims</h4>We evaluated the clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in HL survivors.<h4>Methods</h4>In all, 101 HL survivors (median age 51 years, median age of HL diagnosis 25 years) underwent colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas/serrated l ...[more]