Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin's lymphoma survivors.

ABSTRACT:

Background

Hodgkin's lymphoma (HL) survivors treated with abdominal radiotherapy and/or procarbazine have an increased risk of developing colorectal neoplasia.

Aims

We evaluated the clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in HL survivors.

Methods

In all, 101 HL survivors (median age 51 years, median age of HL diagnosis 25 years) underwent colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas/serrated lesions or colorectal cancer), mostly right-sided, were detected, as published previously. An average-risk asymptomatic cohort who underwent screening colonoscopy were controls (median age 60 years). Clinicopathological characteristics of AN were evaluated in both groups. Mismatch repair (MMR) status

SUBMITTER: Ykema BLM 

PROVIDER: S-EPMC9290704 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature