Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging.

ABSTRACT:

Background

Partial bile duct ligation (PBDL) model is a reliable cholestatic fibrosis experimental model that showed complex histopathological changes. Magnetic resonance imaging (MRI) features of PBDL have not been well characterized.

Purpose

To investigate the potential of MRI parameters in assessing fibrosis in PBDL and explore the relationships between MRI and pathological features.

Animal model

Established PBDL models.

Population

Fifty-four mice were randomly divided into four timepoints PBDL groups and one sham group.

Field strength/sequence

3.0 T; MRI sequences included T1-weighted fast spin-echo (FSE), T2-weighted single shot FSE, variable flip angle T1 mapping, multi-echo SE T2 mapping, multi-echo gradient-echo T2* mapping, and multi-b-value dif

SUBMITTER: Liu JY 

PROVIDER: S-EPMC9290705 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature