Review article: therapeutic aspects of bile acid signalling in the gut-liver axis.

ABSTRACT:

Background

Bile acids are important endocrine modulators of intestinal and hepatic signalling cascades orchestrating critical pathophysiological processes in various liver diseases. Increasing knowledge on bile acid signalling has stimulated the development of synthetic ligands of nuclear bile acid receptors and other bile acid analogues.

Aim

This review summarises important aspects of bile acid-mediated crosstalk between the gut and the liver ("gut-liver axis") as well as recent findings from experimental and clinical studies.

Methods

We performed a literature review on bile acid signalling, and therapeutic applications in chronic liver disease.

Results

Intestinal and hepatic bile acid signalling pathways maintain bile acid homeostasis. Perturbations of bile a

SUBMITTER: Simbrunner B 

PROVIDER: S-EPMC9290708 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature