Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF.

ABSTRACT:

Aims

Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF).

Methods and results

We performed a retrospective post-hoc analysis including patients from both the index and validation BIOSTAT-CHF cohorts with data regarding MR status. The primary endpoint was a composite of all-cause death or HF hospitalization. Among 4023 patients included, 1653 patients (41.1%) had moderate-severe MR. Compared to others, patients with moderate-severe MR were more likely to have atrial fibrillation and chronic kidney disease and had larger left ventricular (LV) dime

SUBMITTER: Pagnesi M 

PROVIDER: S-EPMC9290728 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature