Repeat donation and deferral rates in US source plasma donors: Exploratory analysis from the IMPACT trial.

ABSTRACT:

Background

The IMPACT trial demonstrated the safety of a new personalized nomogram for plasma donation and provided an opportunity to explore short- to mid-term impact on repeat donation and deferral rates, and factors affecting these.

Study design and methods

In the IMPACT trial, participants were randomized to donate plasma using an established weight-based nomogram (control) versus a new personalized nomogram incorporating height, weight, and hematocrit (experimental). In this exploratory analysis, repeat donations (per donor, by study arm) were analyzed using negative binomial generalized linear regression models and descriptive statistics. The mean number of donor deferral events was compared between the two arms using logistic regression and count data modeling approac

SUBMITTER: Hartmann J 

PROVIDER: S-EPMC9290731 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature