The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα⁺ intraepithelial lymphocyte precursors.

ABSTRACT: While T cell receptor (TCR) αβ⁺CD8α⁺CD8β^- intraepithelial lymphocytes (CD8αα⁺ IELs) differentiate from thymic IEL precursors (IELps) and contribute to gut homeostasis, the transcriptional control of their development remains poorly understood. In the present study we showed that mouse thymocytes deficient for the transcription factor leukemia/lymphoma-related factor (LRF) failed to generate TCRαβ⁺CD8αα⁺ IELs and their CD8β-expressing counterparts, despite giving rise to thymus and spleen CD8αβ⁺ T cells. LRF-deficient IELps failed to migrate to the intestine and to protect against T cell-induced colitis, and had impaired expression of the gut-homing integrin α4β7. Single-cell RNA-sequencing found that LRF was neces

SUBMITTER: Nie J 

PROVIDER: S-EPMC9290758 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature