NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment.

ABSTRACT:

Purpose

Diffusion MRI offers insight into ischemic stroke progression in both human and rodent models. However, diffusion MRI to evaluate therapeutic application of mesenchymal stem cells is limited. Robust analytical techniques are required to identify potential physiological changes as a function of cell therapy in stroke. Here, we seek to establish Neurite Orientation Dispersion and Density Imaging (NODDI) as a feasible method in evaluating stroke evolution in response to cell-based therapeutics.

Methods

Diffusion MRI data at 21.1T were acquired from 16 male rats. Rats were grouped randomly: naïve (baseline, N = 5), stroke with injections of phosphate buffered saline (N = 6), stroke with injection of 2D human mesenchymal stem cells (hMSC, N = 5). Data were acquired on day

SUBMITTER: Bagdasarian FA 

PROVIDER: S-EPMC9290760 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature