Muscle architecture is associated with muscle fat replacement in Duchenne and Becker muscular dystrophies.

ABSTRACT:

Introduction/aims

Duchenne and Becker muscular dystrophies (DMD and BMD, respectively) are characterized by fat replacement of different skeletal muscles in a specific temporal order. Given the structural role of dystrophin in skeletal muscle mechanics, muscle architecture could be important in the progressive pathophysiology of muscle degeneration. Therefore, the aim of this study was to assess the role of muscle architecture in the progression of fat replacement in DMD and BMD.

Methods

We assessed the association between literature-based leg muscle architectural characteristics and muscle fat fraction from 22 DMD and 24 BMD patients. Dixon-based magnetic resonance imaging estimates of fat fractions at baseline and 12 (only DMD) and 24 months were related to fiber length an

SUBMITTER: Veeger TTJ 

PROVIDER: S-EPMC9290788 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature