Complications, compliance, and undertreatment do not explain the relationship between cognition and survival in diffuse glioma patients.

ABSTRACT:

Background

Cognitive deficits occur in all different grades of glioma. In a recent study, we found these deficits to be independently, and possibly causally, related to survival in diffuse gliomas. In this study, we investigated whether the relationship between cognition and survival was mediated by three different factors: undertreatment, complications of treatment, and compliance. We hypothesized that patients with cognitive impairment may undergo less intensive treatment, be less compliant, and suffer more from complications, resulting in shortened survival for cognitively impaired patients.

Methods

In a retrospective cohort study of patients undergoing awake craniotomy between operative neuropsychological assessments in five cognitive domains. We used Structural Equation

SUBMITTER: van Kessel E 

PROVIDER: S-EPMC9290897 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature