Early motor outcomes in infants with critical congenital heart disease are related to neonatal brain development and brain injury.

ABSTRACT:

Aim

To assess the relationship between neonatal brain development and injury with early motor outcomes in infants with critical congenital heart disease (CCHD).

Method

Neonatal brain magnetic resonance imaging was performed after open-heart surgery with cardiopulmonary bypass. Cortical grey matter (CGM), unmyelinated white matter, and cerebellar volumes, as well as white matter motor tract fractional anisotropy and mean diffusivity were assessed. White matter injury (WMI) and arterial ischaemic stroke (AIS) with corticospinal tract (CST) involvement were scored. Associations with motor outcomes at 3, 9, and 18 months were corrected for repeated cardiac surgery.

Results

Fifty-one infants (31 males, 20 females) were included prospectively. Median age at neonatal surgery

SUBMITTER: Stegeman R 

PROVIDER: S-EPMC9290970 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature