Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla_CTX-M-15 infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.

ABSTRACT: The emergence of mobile mcr genes mediating resistance to colistin is a critical public health issue that has hindered the treatment of serious infections caused by multidrug-resistant pathogens in humans and other animals. We report the emergence of the mcr-9.1 gene in a polymyxin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacter kobei infecting a free-living franciscana dolphin (Pontoporia blainvillei), threatened with extinction in South America. Genomic analysis confirmed the presence of genes conferring resistance to clinically relevant β-lactam [bla_CTX-M-15 , bla_ACT-9 , bla_OXA-1 and bla_TEM-1B ], aminoglycoside [aac(3)-IIa, aadA1, aph(3'')-Ib and aph(6)-Id], trimethoprim [dfrA14], tetracycline [tetA], quinolone [aac(6')-I

SUBMITTER: Fuentes-Castillo D 

PROVIDER: S-EPMC9290994 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature