Assessment of a diaphragm override strategy for robustly optimized proton therapy planning for esophageal cancer patients.

ABSTRACT:

Purpose

To ensure target coverage in the treatment of esophageal cancer, a density override to the region of diaphragm motion can be applied in the optimization process. Here, we evaluate the benefit of this approach during robust optimization for intensity modulated proton therapy (IMPT) planning.

Materials and methods

For 10 esophageal cancer patients, two robustly optimized IMPT plans were created either using (WDO) or not using (NDO) a diaphragm density override of 1.05 g/cm³ during plan optimization. The override was applied to the excursion of the diaphragm between exhale and inhale. Initial robustness evaluation was performed for plan acceptance (setup errors of 8 mm, range errors of ±3%), and subsequently, on all weekly repeated 4DCTs (setup errors of 2 mm

SUBMITTER: Visser S 

PROVIDER: S-EPMC9291176 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature