Potential determinants of the E/e' ratio in non-dialysis compared with dialysis patients.

ABSTRACT:

Aim

We hypothesized that arterial function and N-terminal natriuretic peptide (NT-proBNP) levels as a marker of volume overload, relate differently to E/e' as an index of diastolic function in dialysis compared with non-dialysis patients with chronic kidney disease. We further examined whether cardiovascular risk factors attenuated these relationships.

Methods

We assessed cardiovascular risk factors and determined arterial function indices by applanation tonometry using SphygmoCor software and E/e' by echocardiography in 103 (62 non-dialysis and 41 dialysis) patients.

Results

In established confounder adjusted analysis, dialysis status impacted the pulse wave velocity-E/e' relationship (interaction p = .01) but not the NT-proBNP level-E/e' association (interaction p =

SUBMITTER: Hsu HC 

PROVIDER: S-EPMC9291212 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature