Combinations of peptides synergistically activate the regenerative capacity of skin cells in vitro.

ABSTRACT:

Objective

To explore synergistic effects related to skin regeneration, peptides with distinct biological mechanisms of action were evaluated in combination with different skin cell lines in the presence or absence of niacinamide (Nam). Furthermore, the synergistic responses of peptide combinations on global gene expression were compared with the changes that occur with fractional laser resurfacing treatment, a gold standard approach for skin rejuvenation, to further define optimal peptide combinations.

Methods

Microarray profiling was used to characterize the biological responses of peptide combinations (+/- Nam) relative to the individual components in epidermal keratinocyte and dermal fibroblast cell lines. Cellular functional assays were utilized to confirm the synergisti

SUBMITTER: Flagler MJ 

PROVIDER: S-EPMC9291327 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature