First-line therapies in late-onset multiple sclerosis: An Italian registry study.

ABSTRACT:

Background and purpose

The diagnosis of late-onset (age ≥50 years old) relapsing remitting multiple sclerosis (LORRMS) has been increasingly described in clinical practice, whereas data focusing on the specific therapeutic management of LORRMS are scarce. Our objective was to compare the effectiveness of injectable and oral first-line disease-modifying therapies (DMTs) in a cohort of LORRMS patients with time to first relapse, time to confirmed disability progression (CDP), and time to discontinuation.

Methods

This is a multicenter, observational, retrospectively acquired cohort study on LORRMS-naïve patients from the Italian MS Register who started either injectable or oral first-line DMTs between January 1, 2013 and December 31, 2017. LORRMS patients were divided into two

SUBMITTER: Zanghi A 

PROVIDER: S-EPMC9291454 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature