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Synthesis and Transformations of NH-Sulfoximines.

ABSTRACT: Recent years have seen a marked increase in the occurrence of sulfoximines in the chemical sciences, often presented as valuable motifs for medicinal chemistry. This has been prompted by both pioneering works taking sulfoximine containing compounds into clinical trials and the concurrent development of powerful synthetic methods. This review covers recent developments in the synthesis of sulfoximines concentrating on developments since 2015. This includes extensive developments in both S-N and S-C bond formations. Flow chemistry processes for sulfoximine synthesis are also covered. Finally, subsequent transformations of sulfoximines, particularly in N-functionalization are reviewed, including N-S, N-P, N-C bond forming processes and cyclization reactions.

SUBMITTER: Andresini M

PROVIDER: S-EPMC9291533 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Synthesis and Transformations of NH-Sulfoximines.

Andresini Michael M Tota Arianna A Degennaro Leonardo L Bull James A JA Luisi Renzo R

Chemistry (Weinheim an der Bergstrasse, Germany) 20211013 69

Recent years have seen a marked increase in the occurrence of sulfoximines in the chemical sciences, often presented as valuable motifs for medicinal chemistry. This has been prompted by both pioneering works taking sulfoximine containing compounds into clinical trials and the concurrent development of powerful synthetic methods. This review covers recent developments in the synthesis of sulfoximines concentrating on developments since 2015. This includes extensive developments in both S-N and S ...[more]

PMID: 34519376

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Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides.

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