Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer.

ABSTRACT:

Background

The Khorana score is a validated tool to identify cancer patients at higher risk of venous thromboembolism (VTE).

Objective

We compared its predictive performance to that of the clinical PROTECHT and the polygenic 5-SNP scores in patients who participated in the Dutch CPCT-02 study.

Patients/methods

Data on VTE and its risk factors were retrospectively collected for 2729 patients with advanced stage solid tumors planned for systemic cancer treatment. Patients were followed for 6 months. Overall discriminatory performance of the scores was evaluated by time-dependent c-indices. The scores were additionally evaluated dichotomously in competing risk models.

Results

A total of 160 (5.9%) patients developed VTE during follow-up. Time-dependent c-indices a

SUBMITTER: Guman NAM 

PROVIDER: S-EPMC9291564 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature