Depletion of CD8⁺ T cells from vaccinated goats does not affect protection from challenge with wild-type peste des petits ruminants virus.

ABSTRACT: Peste des petits ruminants (PPR) is a severe disease of goats and sheep that is widespread in Africa, the Middle East and Asia. The disease is caused by peste des petits ruminants virus (PPRV); cell culture-attenuated strains of PPRV have been shown, both experimentally and by extensive use in the field, to be effective vaccines and are widely used. We have previously demonstrated that these vaccines elicit both serological (PPRV-specific antibody) and cell-based (PPRV-specific CD4⁺ and CD8⁺ T cells) immune responses. However, it is not known which of these responses are required for protection from PPRV, information that would be useful in the evaluation of new vaccines that are being developed to provide the capability to differentiate infected and vaccinated animal

SUBMITTER: Baron MD 

PROVIDER: S-EPMC9291567 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature