A benchmark for dose-finding studies with unknown ordering.

ABSTRACT: An important tool to evaluate the performance of a dose-finding design is the nonparametric optimal benchmark that provides an upper bound on the performance of a design under a given scenario. A fundamental assumption of the benchmark is that the investigator can arrange doses in a monotonically increasing toxicity order. While the benchmark can be still applied to combination studies in which not all dose combinations can be ordered, it does not account for the uncertainty in the ordering. In this article, we propose a generalization of the benchmark that accounts for this uncertainty and, as a result, provides a sharper upper bound on the performance. The benchmark assesses how probable the occurrence of each ordering is, given the complete information about each patient. The proposed a

SUBMITTER: Mozgunov P 

PROVIDER: S-EPMC9291639 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature