Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels.

ABSTRACT: Promising active pharmaceutical ingredients (APIs) often exhibit poor aqueous solubility and thus a low bioavailability that substantially limits their pharmaceutical application. Hence, efficient formulations are required for an effective translation into highly efficient drug products. One strategy is the preservation of an amorphous state of the API within a carrier matrix, which leads to enhanced dissolution. In this work, mesoporous silica aerogels (SA) were utilized as a carrier matrix for the amorphization of the poorly water-soluble model drug ibuprofen. Loading of tailored SA was performed post-synthetically and solvent-free, either by co-milling or via the melting method. Thorough analyses of these processes demonstrated the influence of macrostructural changes during the drying

SUBMITTER: Zarinwall A 

PROVIDER: S-EPMC9291651 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature