Characterization of the oral microbiome of children with type 1 diabetes in the acute and chronic phases.

ABSTRACT:

Background and aim

The relationship between the oral microbiota and type 1 diabetes (T1D) remains unclear. We aimed to evaluate the variations in the oral microbiome in T1D and identify potentially associated bacterial factors.

Methods

We performed high-throughput sequencing of the V3-V4 area of the 16S rRNA gene to profile the oral bacterial composition of 47 healthy children (CON group), 46 children with new-onset T1D in the acute phase (NT1D group), and 10 children with T1D in the chronic phase receiving insulin treatment (CT1D group). Multivariate statistical analysis of sequencing data was performed.

Results

Compared to the CON group, the NT1D group was characterized by decreased diversity and increased abundance of genera harboring opportunistic pathogens

SUBMITTER: Yuan X 

PROVIDER: S-EPMC9291685 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature